Yellow reaction products from tocopherols and trimethylamine oxide.
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منابع مشابه
Purification and properties of trimethylamine oxide reductase from Salmonella typhimurium.
The major inducible trimethylamine oxide reductase was purified from Salmonella typhimurium LT2. The molecular weights of the native enzyme were estimated to be 332,000 by gel filtration and 170,000 by nondenaturing disc gel electrophoresis. In sodium dodecyl sulfate-gel electrophoresis, the enzyme formed a single band of molecular weight 84,000. The isoelectric point was 4.28. Maximum activity...
متن کاملTrimethylamine oxide excretion rates in elasmobranchs.
GOLDSTEIN, LEON, AND PAUL J. PALATT. Trimethylamine oxide excretion rates in elasmobranchs. Am. J. Physiol. 227(6) : 1268-1272. 1974.-The purpose of this study was to investigate the relationship between rates of excretion and rates of biosynthesis of trimethylamine oxide (TMAO) in elasmobranchs. TMAO excretion rates were estimated in four elasmobranchs previously shown to differ in their abili...
متن کاملThe biosynthesis of trimethylamine-N-oxide.
Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in vitro. The additional requirement for redu...
متن کاملBlood Trimethylamine-N-Oxide Originates from Microbiota Mediated Breakdown of Phosphatidylcholine and Absorption from Small Intestine
Elevated serum trimethylamine-N-oxide (TMAO) was previously reported to be associated with an elevated risk for cardiovascular events. TMAO originates from the microbiota-dependent breakdown of food-derived phosphatidylcholine (PC) to trimethylamine (TMA), which is oxidized by hepatic flavin-containing monooxygenases to TMAO. Our aim was to investigate the predominant site of absorption of the ...
متن کاملStructural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.
Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monooxygenase (Tmm), a bacterial flavin-containing monooxygenase (FMO), is found widespread in marine bacteria and is responsible for converting TMA to TMAO. However, the molecular mechanism of TMA oxygenation by Tmm has not been explained. Here, we determined t...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1974
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.38.2545